Is VOYDEYA right for me?
What is VOYDEYA?
- VOYDEYA is an oral medication taken with ULTOMIRIS® (ravulizumab-cwvz) or SOLIRIS® (eculizumab) designed to help treat ongoing symptoms of anemia, such as fatigue, due to EVH in adult patients with PNH
How do I know if I have EVH?
-
Some people living with PNH who are on ULTOMIRIS or SOLIRIS can
continue to experience anemia. Anemia can lead to fatigue that
impacts your ability to do the things you want, and in some, the
need for blood transfusions - You may be experiencing EVH if you have:
- persistent symptoms of anemia, such as fatigue, and sometimes the need for blood transfusions
- low levels of hemoglobin
-
high levels of immature red blood
cells (reticulocytes) - Because ongoing anemia can have different causes, including iron deficiencies or bone marrow failure, it is important that all causes are ruled out
I’m currently taking ULTOMIRIS or SOLIRIS. Will adding VOYDEYA impact my current treatment?
- VOYDEYA is added to ULTOMIRIS or SOLIRIS to treat ongoing anemia due to EVH without disrupting your current treatment
My child has PNH. Can they take VOYDEYA?
- VOYDEYA is approved for adult patients 18 years of age or older with PNH. The safety and efficacy of VOYDEYA for the treatment of EVH in pediatric patients (<18 years old) with PNH have not been established
Clinical studies
Who participated in the VOYDEYA clinical trial?
-
VOYDEYA has been studied in adult patients 18 years of age or
older who
had PNH and were experiencing ongoing anemia due to EVH, and who have been on a stable dose of either ULTOMIRIS or SOLIRIS for at least 6 months
was studied >
What is a FACIT-Fatigue score?
- The Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue score is based on a questionnaire that patients in the study answered to track their level of fatigue and how fatigue impacted their daily activities and function
-
FACIT-Fatigue scores can range from
0 to 52, with higher scores indicating
less fatigue - The average FACIT-Fatigue score for patients at the start of the study was about 34 points
- People without PNH have an average FACIT-Fatigue score of 43.5 points
Safety information
How many vaccines do I need before I can take VOYDEYA?
-
You must be up to date on the meningococcal vaccines—and
potentially other vaccines as determined by your healthcare provider—as part of your treatment regimen
What are the side effects of VOYDEYA?
- The most common side effect was headache. Other side effects included: vomiting, fever, elevated liver enzymes shown on a blood test, high blood pressure, and pain in arms or legs
Can I stop taking ULTOMIRIS and/or VOYDEYA if my symptoms improve?
- PNH is a chronic disease and treatment with ULTOMIRISa is recommended to be continued, unless stopping treatment is medically necessary. Talk to your healthcare provider for more information
- As your symptoms improve, it’s important to continue to take ULTOMIRISa to keep the most severe aspects of PNH under control
- Do not stop treatment with VOYDEYA for your EVH without first discussing with your healthcare provider
aVOYDEYA may also be taken with SOLIRIS.
Can I take VOYDEYA with other medications?
- VOYDEYA must be taken with either ULTOMIRIS or SOLIRIS. Speak to your healthcare provider about additional medications you may be taking, including any over-the-counter medications or supplements you may be taking or plan to take
Can I take VOYDEYA while pregnant?
- VOYDEYA has not been studied in pregnant individuals. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your healthcare provider for advice before taking VOYDEYA
Are there any ingredients in VOYDEYA that are known to cause allergic reactions?
- VOYDEYA contains lactose. If your healthcare provider has told you that you have an allergy or intolerance to lactose, contact your healthcare provider before taking this medicine
a full list of ingredients >
Dosing guidance
How does VOYDEYA dosing work?
- The recommended starting dosage for VOYDEYA is 150 mg, taken orally 3 times a day
- Depending on your response to treatment, your healthcare provider may increase your dosage to 200 mg, 3 times a day
- For both the 150 mg dose and the 200 mg dose, you’ll be taking 2 tablets at a time
Can I crush, split, or dissolve VOYDEYA before taking it?
-
Please refer to the “How should I take VOYDEYA?” section of the
VOYDEYA Medication Guide for dosing
instructions - Speak with your healthcare provider or pharmacist, if needed, for guidance if you are having trouble taking your medicine
Do I need to take VOYDEYA with food?
- VOYDEYA can be taken with or without food
What if I miss a dose?
- If you miss a dose of VOYDEYA, take it as soon as possible unless it’s almost time for your next dose (within 3 hours). If that’s the case, skip the missed dose. Then, take the next dose at the normal time
- If you miss a dose, your foundational therapy is designed to manage the most severe aspects of PNH
- Do not take more than 2 tablets of VOYDEYA at a time to make up for a missed dose
Supply and storage
What does VOYDEYA look like?
- VOYDEYA is a round, white oral tablet that is packaged based on the dose prescribed by your healthcare provider
-
If you are prescribed a dose of
150 mg, each package will contain 1 bottle of 100 mg (90 tablets) and 1 bottle of 50 mg (90 tablets) for a 30-day supply -
If you are prescribed a dose of
200 mg, each package will contain 2 bottles of 100 mg (90 tablets per each bottle) for a 30-day supply
Tablet images are for example only.
How should VOYDEYA be stored?
-
VOYDEYA does not need to be
refrigerated and does not require any special storage conditions - VOYDEYA should be stored in its original container at room temperature, between 20°C and 25°C (68°F and 77°F)
- VOYDEYA should not be used after the expiration date printed on the carton and bottle
- VOYDEYA should be kept out of the sight and reach of children
Support
Are patient support services available with VOYDEYA?
- Alexion’s OneSource™ is a program that provides patients with personalized support throughout their treatment journey
-
OneSource helps you navigate your
health insurance and also provides support for disease information and community connections - By adding VOYDEYA to ULTOMIRIS or SOLIRIS, you’ll be able to work with a dedicated support team who knows you and your treatment plan. They can answer questions about your medicine, help you navigate your insurance, and direct you to financial support programs
- Talk with your healthcare provider about programs that could help support you while you’re on treatment with VOYDEYA
